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Our Publications

Welcome to Jacox Lab's collection of research manuscripts. Browse our publications below to learn more about our research and findings. If you have any questions or suggestions, do not hesitate to reach out to us.

Impacts of Jaw Surgery on Speech in Class III Patients

Rezende Silva, E., Bode, C.S., Lowry, G. et al. Impacts of jaw surgery on speech in Class III patients. Nat Commun (2026). https://doi.org/10.1038/s41467-026-71495-9.

Parent Perceptions of Animal-Assisted Therapy for Pediatric Dental Patients with Special Health Care Needs: A Pilot Survey Study

Roa V, Castro M, Sangalli L, Jacox L, Sawicki CM. Parent Perceptions of Animal-Assisted Therapy for Pediatric Dental Patients with Special Health Care Needs: A Pilot Survey Study. Pediatr Dent. 2026 Jan 15;48(1):38-46. PMID: 41803656.

Evaluating Effects of Animal-Assisted Therapy on Pediatric Dental Care Patients: A Pilot Clinical Trial

Massouda J, Ghaltakhchyan N, Judd J, Bocklage C, Selden R, TumSuden O, Nanney E, Lee J, Ginnis J, Strauman T, Sawicki C, Hodges EA, Graves C, Divaris K, Jacox L. Evaluating effects of animal-assisted therapy on pediatric dental care patients: A pilot clinical trial. J Am Dent Assoc. 2025 Jun;156(6):447-457.e14. doi: 10.1016/j.adaj.2025.03.006. PMID: 40467121; PMCID: PMC12356166.

A Software-based Observational Coding Approach for Evaluating Paediatric Dental Pain, Anxiety, and Fear

Bocklage C, Selden R, Tumsuden O, et al. A software-based observational coding approach for evaluating paediatric dental pain, anxiety, and fear. Int J Paediatr Dent. 2024; 00: 1-18. doi:10.1111/ipd.13227

Influence of BMI Percentile on Craniofacial Morphology and Development in Adolescents, Part II: Elevated BMI is Associated with Larger Final Facial Dimensions 

Hancock, S., Carmack, A., Kocher, M., Rezende Silva, E., Sulkowski, T., Nanney, E., Graves, C., Mitchell, K., & Jacox, L. A. Influence of BMI percentile on craniofacial morphology and development in adolescents,Part II: Elevated BMI is associated with larger final facial dimensions. European Journal of Orthodontics. https://doi.org/10.1093/ejo/cjad043

Evaluating Video-based Lectures on YouTube for Dental Education

Gross RT, Ghaltakhchyan N, Nanney EM, et al. Evaluating video-based lectures on YouTube for dental education [published online ahead of print, 2023 May 15]. Orthod Craniofac Res. 2023;10.1111/ocr.12669. doi:10.1111/ocr.12669

Validating Spectral Moment Analysis as a Quantitative Measure of Speech Distortions in Speakers With Class III Malocclusions

Jhingree S, Xie Y, Bocklage C, et al. Validating Spectral Moment Analysis as a Quantitative Measure of Speech Distortions in Speakers With Class III Malocclusions. Perspect ASHA Spec Interest Groups. 2022;7(3):728-740. doi:10.1044/2022_persp-21-00315

Understanding Technology Adoption by Orthodontists: A Quantitative Study

Jacox LA, Bocklage C, Edwards T, Mihas P, Lin FC, Ko CC. Understanding technology adoption by orthodontists: A quantitative study. Am J Orthod Dentofacial Orthop. 2022;161(3):364-374. doi:10.1016/j.ajodo.2020.08.024

Pediatrics, Craniofacial and Orthognathic Surgery Track: Impacts of Dentofacial Disharmony and its Surgical Correction on Speech

Jacox, Laura Anne, et al. “Pediatrics, Craniofacial and Orthognathic Surgery Track: Impacts of Dentofacial Disharmony and Its Surgical Correction on Speech.” Journal of Oral and Maxillofacial Surgery, vol. 81, no. 10, Oct. 2023, pp. e9–10. DOI.org (Crossref), https://doi.org/10.1016/j.joms.2023.08.187.

Patient and Caregiver Perceptions of Animal Assisted Activity in Orthodontics

Cass K, Bocklage C, Sulkowski T, Graves C, Ghaltakhchyan N, Rapolla A, Jackson T, Divaris K, Wiesen C, Strauman T, Jacox L. Patient and Caregiver Perceptions of Animal Assisted Activity in Orthodontics. Animals (Basel). 2022 Jul 21;12(14):1862. doi: 10.3390/ani12141862. PMID: 35883412; PMCID: PMC9312150.

Understanding Technology Adoption by Orthodontists: A Qualitative Study 

Jacox LA, Mihas P, Cho C, Lin FC, Ko CC. Understanding technology adoption by orthodontists: A qualitative study. Am J Orthod Dentofacial Orthop. 2019;155(3):432-442. doi:10.1016/j.ajodo.2018.08.018

Impacts of Development, Dentofacial Disharmony, and Its Surgical Correction on Speech: A Narrative Review for Dental Professionals

Bode C, Ghaltakhchyan N, Silva ER, et al. Impacts of Development, Dentofacial Disharmony, and Its Surgical Correction on Speech: A Narrative Review for Dental Professionals. Appl Sci (Basel). 2023;13(9):5496. doi:10.3390/app13095496

Mouth Development

Chen J, Jacox LA, Saldanha F, Sive H. Mouth development. Wiley Interdiscip Rev Dev Biol. 2017 Sep;6(5):e275. doi: 10.1002/wdev.275. Epub 2017 May 17. PMID: 28514120; PMCID: PMC5574021.

Facial Transplants in Xenopus laevis Embryos

Jacox LA, Dickinson AJ, Sive H. Facial transplants in Xenopus laevis embryos. J Vis Exp. 2014 Mar 26;(85):50697. doi: 10.3791/50697. PMID: 24748020; PMCID: PMC4089428.

Longitudinal Outcomes of Bone-Anchored Maxillary Protraction Treatment

Esposito C, Judd J, Rezende Silva E, Xie J, Blakey G, Jacox LA. Longitudinal outcomes of bone-anchored maxillary protraction treatment. Am J Orthod Dentofacial Orthop. 2026 Jul 27:S0889-5406(26)00293-3. doi: 10.1016/j.ajodo.2026.04.018. Epub ahead of print. PMID: 42506953.

A Lingual Ultrasound Study of Speech in Patients With Cleft Lip and Palate Following Orthognathic Surgery

Lowry G, Rezende Silva E, Matthews J, Shoji A, Turvey T, Blakey G, Zajac D, Mielke J, Jacox LA. A Lingual Ultrasound Study of Speech in Patients With Cleft Lip and Palate Following Orthognathic Surgery. Orthod Craniofac Res. 2025 Apr 11. doi: 10.1111/ocr.12926. 

A Cetylpyridinium Chloride Oral Rinse Reduces Salivary Viral Load in Randomized Controlled Trials

Graves C, Ghaltakhchyan N, Ngo TQ, Liu C, Babikow E, Shoji A, Bocklage C, Sang Y, Phillips ST, Bowman N, Frazier-Bowers S, Freire M, Wallet S, Divaris K, Wu D, Jacox LA. A Cetylpyridinium Chloride Oral Rinse Reduces Salivary Viral Load in Randomized Controlled Trials. JDR Clin Trans Res. 2024 Dec 9:23800844241296840. doi: 10.1177/23800844241296840.

Multitaper Spectrum Analysis of Consonants Produced by Patients With Dentofacial Disharmonies

Tran A, Oakley M, Paye C, et al. Multitaper Spectrum Analysis of Consonants Produced by Patients With Dentofacial Disharmonies. Journal of Speech, Language, and Hearing Research. doi:doi:10.1044/2023_JSLHR-23-00280

Longitudinal Microbiome Changes in Supragingival Biofilm Transcriptomes Induced by Orthodontics

Babikow E, Ghaltakhchyan N, Livingston T, et al. Longitudinal Microbiome Changes in Supragingival Biofilm Transcriptomes Induced by Orthodontics [published online ahead of print, 2023 Oct 24]. JDR Clin Trans Res. 2023;23800844231199393. doi:10.1177/23800844231199393

Impacts of Anterior-Posterior Jaw Disproportions on Speech of Dentofacial Disharmony Patients

Oliver S, Keyser MMB, Jhingree S, et al. Impacts of anterior-posterior jaw disproportions on speech of dentofacial disharmony patients. Eur J Orthod. 2023;45(1):1-10. doi:10.1093/ejo/cjac057

Effects of the COVID-19 Pandemic on Dentists' Workforce Confidence and Workflow

Liu DZ, Gallo GN, Babikow E, et al. Effects of the COVID-19 pandemic on dentists' workforce confidence and workflow. J Am Dent Assoc. 2022;153(7):610-624.e8. doi:10.1016/j.adaj.2021.11.011

Orthognathic Speech Pathology: Impacts of Class III Malocclusion on Speech

Lathrop-Marshall H, Keyser MMB, Jhingree S, et al. Orthognathic speech pathology: impacts of Class III malocclusion on speech. Eur J Orthod. 2022;44(3):340-351. doi:10.1093/ejo/cjab067

Educational Debt and the Gender Gap: Understanding Factors Influencing Orthodontists' Career Decisions

Worthington CC, Mihas P, Bocklage C, et al. Educational debt and the gender gap: Understanding factors influencing orthodontists' career decisions. Am J Orthod Dentofacial Orthop. 2022;161(1):e20-e61. doi:10.1016/j.ajodo.2020.10.027

Roles of Autophagy in Orthodontic Tooth Movement

Li Y, Jacox LA, Coats S, et al. Roles of autophagy in orthodontic tooth movement. Am J Orthod Dentofacial Orthop. 2021;159(5):582-593. doi:10.1016/j.ajodo.2020.01.027

Orthodontic Tooth Movement: The Biology and Clinical Implications 

Li Y, Jacox LA, Little SH, Ko CC. Orthodontic tooth movement: The biology and clinical implications. Kaohsiung J Med Sci. 2018;34(4):207-214. doi:10.1016/j.kjms.2018.01.007

Patient and Caregiver Perceptions of Animal Assisted Activity in Orthodontics

Cass K, Bocklage C, Sulkowski T, et al. Patient and Caregiver Perceptions of Animal Assisted Activity in Orthodontics. Animals (Basel). 2022;12(14):1862. Published 2022 Jul 21. doi:10.3390/ani12141862

Formation of a "Pre-mouth Array" from the Extreme Anterior Domain Is Directed by Neural Crest and Wnt/PCP Signaling

Jacox L, Chen J, Rothman A, Lathrop-Marshall H, Sive H. Formation of a "Pre-mouth Array" from the Extreme Anterior Domain Is Directed by Neural Crest and Wnt/PCP Signaling. Cell Rep. 2016 Aug 2;16(5):1445-1455. doi: 10.1016/j.celrep.2016.06.073. Epub 2016 Jul 14. PMID: 27425611; PMCID: PMC4972695.

A Novel Kinin-Kallikrein Pathway Regulates Vertebrate Mouth Formation

Sindelka, R., Jacox, L., Dickinson, A. and Sive, H. (2012), A novel kinin-kallikrein pathway regulates vertebrate mouth formation. FASEB J, 26: 339.1-339.1. https://doi.org/10.1096/fasebj.26.1_supplement.339.1

​Weight-Related Considerations for Orthodontic Treatment: A Quantitative Survey Study

Hezarkhani, Elmira, et al. “Weight-Related Considerations for Orthodontic Treatment: A Quantitative Survey Study.” AJO-DO Clinical Companion, July 2026, p. S2666430526001160. DOI.org (Crossref), https://doi.org/10.1016/j.xaor.2026.07.004.

Effects of Animal-Assisted Therapy on Dental Anxiety, Behavior, and Perceptions in Young Pediatric Patients: a Blinded Randomized Controlled Trial

Kapov G, Linton K, Gatewood C, Liu C, Strauman T, Hodges E, Graves C, Sawicki C, Wu D, Divaris K, Jacox LA. Effects of animal-assisted therapy on dental anxiety, behavior, and perceptions in young pediatric patients: a blinded randomized controlled trial. Trials. 2025 Aug 7;26(1):279. doi: 10.1186/s13063-025-08970-z. PMID: 40775655; PMCID: PMC12330074.

Immune Dysregulation in the Oral Cavity during Early SARS-CoV-2 Infection

Graves C, Babikow E, Ghaltakhchyan N, et al. Immune Dysregulation in the Oral Cavity during Early SARS-CoV-2 Infection. Journal of Dental Research. 2024;0(0). doi:10.1177/00220345241271943

Identifying Factors Influencing Orthodontic Residency Program Selection

Nanney EM, Shumaker A, Gutierrez T, et al. Identifying factors influencing orthodontic residency program selection. J Dent Educ. 2023; 1-10. https://doi.org/10.1002/jdd.13431

Dentofacial Disharmony Patients' Sibilants Differ from Control's More in Source than in Filter Properties

Oakley M, Tran A, Paye C, et al. DENTOFACIAL DISHARMONY PATIENTS' SIBILANTS DIFFER FROM CONTROLS' MORE IN SOURCE THAN FILTER PROPERTIES. Proc Int Congr Phon Sci. 2023;20:823-827.

Impacts of Skeletal Anterior Open Bite Malocclusion on Speech

Keyser MMB, Lathrop H, Jhingree S, et al. Impacts of Skeletal Anterior Open Bite Malocclusion on Speech. FACE (Thousand Oaks). 2022;3(2):339-349. doi:10.1177/27325016221082229

Orthodontic Loading Activates Cell-Specific Autophagy in a Force-Dependent Manner

Jacox LA, Tang N, Li Y, et al. Orthodontic loading activates cell-specific autophagy in a force-dependent manner. Am J Orthod Dentofacial Orthop. 2022;161(3):423-436.e1. doi:10.1016/j.ajodo.2020.09.034

Identifying Factors that Impact General Dentists' Referrals to Orthodontists

Lee DS, Sulkowski T, Bocklage C, et al. Identifying factors that impact general dentists' referrals to orthodontists. Am J Orthod Dentofacial Orthop. 2022;161(2):e147-e171. doi:10.1016/j.ajodo.2021.07.010

Impacts of Anterior-Posterior Jaw Disproportions on Speech of Dentofacial Disharmony Patients

Oliver S, Keyser MMB, Jhingree S, Bocklage C, Lathrop H, Giduz N, Moss K, Blakey G, White R, Turvey T, Mielke J, Zajac D, Jacox LA. Impacts of anterior-posterior jaw disproportions on speech of dentofacial disharmony patients. Eur J Orthod. 2023 Feb 10;45(1):1-10. doi: 10.1093/ejo/cjac057. PMID: 36308520; PMCID: PMC9912703.

Influence of BMI Percentile on Craniofacial Morphology and Development in Children and Adolescents 

​Danze A, Jacox LA, Bocklage C, et al. Influence of BMI percentile on craniofacial morphology and development in children and adolescents. Eur J Orthod. 2021;43(2):184-192. doi:10.1093/ejo/cjaa056

Second Molar Eruption Disturbances in Borderline Extraction Orthodontic Patients

Patrick T, Stickrath K, Christensen J, Jacox L, Mitchell K. Second molar eruption disturbances in borderline extraction orthodontic patients. AJODO. 2024. https://doi.org/10.1016/j.ajodo.2024.06.016

Non-Random Sister Chromatid Segregation in Human Tissue Stem Cells

Panchalingam K, Jacox L, Cappiello BD, Sherley JL. Non-Random Sister Chromatid Segregation in Human Tissue Stem Cells. Symmetry. 2020; 12(11):1868. https://doi.org/10.3390/sym12111868

Role of the Extreme Anterior Domain Organizer in Craniofacial Development 

Jacox L, Sindelka R, Chen J, Rothman A, Dickinson A, Sive H. The extreme anterior domain is an essential craniofacial organizer acting through Kinin-Kallikrein signaling. Cell Rep. 2014 Jul 24;8(2):596-609. doi: 10.1016/j.celrep.2014.06.026. Epub 2014 Jul 17. PMID: 25043181; PMCID: PMC4135435.

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